| 产品详情 |
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| Antigenic Specificity | FAS |
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| Clone | 4F8H6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:200 - 1:400, Immunocytochemistry: 1:200 - 1:1000, Immunofluorescence: 1:200 - 1:1000, Western Blot: 1:500 - 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FAS Monoclonal Antibody (4F8H6). The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/J |
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| Immunogen | n/a |
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| Other Names | ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6 |
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| Gene, Accession # | Entrez: 355; Uniprot: P25445 |
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| Catalog # | MA5-17073 |
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| Price | |
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| Order / More Info | FAS Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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