| 产品详情 |
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| Antigenic Specificity | CD366 (TIM3) |
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| Clone | 8B.2C12 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.25 µg/test, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD366 (TIM3) Monoclonal Antibody (8B.2C12), eBioscience™. TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmun |
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| Immunogen | n/a |
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| Other Names | HAVCR2,TIM-3 |
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| Gene, Accession # | Entrez: 171285; Uniprot: Q8VIM0 |
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| Catalog # | 14-5871-81 |
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| Price | |
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| Order / More Info | CD366 (TIM3) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15905494, 16709797, 17855338, 20819927, 22168579, 22685601, 25172495, 26026061, 28345650 |
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