产品名称 Mouse IL17 Antibody from CREATIVE DIAGNOSTICS
产品货号 CABT-L314
产品价格 现货询价,电话:010-67529703
产品规格 n/a
产品品牌 CREATIVE DIAGNOSTICS
产品概述
产品详情
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Antigenic SpecificityMouse IL17
Clone61212
Host SpeciesRat
Reactive Speciesmouse
IsotypeIgG2a
Formatunconjugated
Sizen/a
Concentrationn/a
ApplicationsELISA(Cap), WB
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DescriptionRat Anti-Mouse IL17 monoclonal antibody for ELISA(Cap), WB. Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. Mouse IL-17 cDNA encodes a 158 amino acid (aa) residue precursor protein with a 21 amino acid residue signal peptide that is cleaved to yield the 137 aa residue mature IL-17. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. At the amino acid level, mouse IL-17 shows 57% and 87% sequence identity with herpes virus and rat IL-17, respectively. An IL-17 specific mouse cell surface receptor (IL-17 R) has been cloned. While the expression of IL-17 mRNA is restricted to activated alpha beta b TCR+CD4-CD8-T cells, the expression of mouse IL-17 R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kappa B and costimulation of T cell proliferation.
ImmunogenRecombinant Protein
Other Namesn/a
Gene, Accession #Gene ID: 16171, UniProt: Q62386
Catalog #CABT-L314
Price
Order / More InfoMouse IL17 Antibody from CREATIVE DIAGNOSTICS
Product Specific Referencesn/a
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