| 产品详情 |
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| Product Name | CAY10410 |
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| Description | CAY10410 is an analog of PGD2/PGJ2 with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-.DELTA.12,14-PGJ2 has been shown to be a potent ligand for PPARγ.{1424} Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and .DELTA.12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone.{7193} CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.{12676} |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 9,10-dihydro-15-deoxy-Δ12,14-PGJ2|9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2 |
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| Gene, Accession, CAS # | CAS: 596104-94-8 |
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| Catalog # | 18590-5 |
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| Price | |
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| Order / More Info | CAY10410 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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