产品名称 A-443654 from CAYMAN CHEMICAL COMPANY
产品货号 16499-5
产品价格 现货询价,电话:010-67529703
产品规格 5 mg
产品品牌 CAYMAN CHEMICAL COMPANY
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Product NameA-443654
DescriptionA pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation; slows the progression of Akt-dependent tumors in vivo; concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction
Size5 mg
Concentrationn/a
Applicationsn/a
Other NamesAkt1 Akt2 Akt3 proteins kinases B PKB cancers cells proliferation inhibitors biochemicals signals tranductions inhibits inhibitions Akt-1 Akt-2 Akt-3 Akts 1 2 3 PK A443654 A 443654 pan isoforms PKBα PKBβ PKBγ α β γ modulates metabolism survivals angiogenesis mitotic progressions bipolar spindles formations induces G2/M G2 M accumulations defects centrosomes separations monopolar arrays disorganized Akt-dependent dependent tumors in vivo mouses models phosphorylation Thr Thr308 308 Ser Ser473 473 humans lines mechanisms rapid feedback reactions
Gene, Accession, CAS #CAS: 552325-16-3
Catalog #16499-5
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Order / More InfoA-443654 from CAYMAN CHEMICAL COMPANY
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