产品名称 A-419259 from CAYMAN CHEMICAL COMPANY
产品货号 25605-5
产品价格 现货询价,电话:010-67529703
产品规格 5 mg
产品品牌 CAYMAN CHEMICAL COMPANY
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Product NameA-419259
DescriptionAn inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, 50 = 3,000 nM) and PKC (IC50 = >33 µM); inhibits growth of Ph+ K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 µM, respectively), but not Ph- TF-1 and HEL cells; induces apoptosis in K-562 cells in a concentration-dependent manner; inhibits differentiation of murine embryonic stem cells while maintaining pluripotency at 300 nM; reduces the total number of AML cells, as well as AML stem cells, in the bone marrow and spleen of human patient-derived AML mouse xenograft models at 30 mg/kg twice daily
Size5 mg
Concentrationn/a
Applicationsn/a
Other NamesRK-20449
Gene, Accession, CAS #CAS: 364042-47-7
Catalog #25605-5
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Order / More InfoA-419259 from CAYMAN CHEMICAL COMPANY
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