| 产品详情 |
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| Antigenic Specificity | CD184 (CXCR4) |
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| Clone | 12G5 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a, kappa |
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| Format | purified |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.5 µg/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD184 (CXCR4) Monoclonal Antibody (12G5), eBioscience™. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 iso |
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| Immunogen | n/a |
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| Other Names | CXC Chemokine Receptor 4, Fusin, LESTR, HUMSTR |
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| Gene, Accession # | Entrez: 7852; Uniprot: P61073 |
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| Catalog # | 14-9999-80 |
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| Price | |
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| Order / More Info | CD184 (CXCR4) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 19502290, 21909361, 23116176, 23277486, 23754844, 23991206, 24490954, 24763614, 24941119, 26379653, 9050881 |
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