| 产品详情 |
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| Product Name | Evacetrapib |
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| Description | A benzazepine-based inhibitor of CETP (IC50s = 5.5 and 26 nM for human recombinant and plasma-derived proteins, respectively); selective for CETP over a panel of cell surface and nuclear receptors at 1 µM; reduces expression of PCSK9 and LDLR in HepG2 cells in a dose-dependent manner; reduces protein levels of LDLR, SREBF2-M, and PCSK9 in HepG2 lysates, nuclear extracts, and culture medium, respectively, in a dose-dependent manner; inhibits CETP activity by 98.5, 98.6, and 18.4% at four, eight, and 24 h, respectively, in CETP/ApoA1 transgenic mice at 30 mg/kg; increases HDL cholesterol levels in serum from CETP/ApoA1 transgenic mice in a dose-dependent manner, including by 129.7% eight hours after a 30 mg/kg dose |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PCSK-9 LDL-R Hep-G2 HepG-2 Apo-A1 LY2484595 LY-2484595 |
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| Gene, Accession, CAS # | CAS: 1186486-62-3 |
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| Catalog # | 23670-5 |
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| Price | |
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| Order / More Info | Evacetrapib from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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