| 产品详情 |
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| Antigenic Specificity | Axl |
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| Clone | MAXL8DS |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, kappa |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.125 µg/test |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Axl Monoclonal Antibody (MAXL8DS), APC, eBioscience™. Axl is a member of the TAM receptor family, which also includes also MerTK and TYRO3. Axl contains protein kinase activity and is activated by dimerization and auto-phosphorylation upon ligand binding. In response to its ligands, Protein S and GAS6, Axl activates anti-inflammatory pathways (through SOCS-1 and SOCS-3), which limits TLR and cytokine signaling. This results in dampened inflammatory responses in macrophages and DCs. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract |
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| Immunogen | n/a |
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| Other Names | ARK, AZF1, UFO, Tyro7 |
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| Gene, Accession # | Entrez: 26362; Uniprot: Q00993 |
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| Catalog # | 17-1084-80 |
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| Price | |
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| Order / More Info | Axl Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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