| 产品详情 |
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| Product Name | Cyclovirobuxine D |
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| Description | An alkaloid with diverse biological activities; ERG channel blocker (IC50 = 19.7 µM using whole-cell patch-clamp electrophysiology in HEK293 cells expressing the human receptor); increases the amount and rate of calcium release from intracellular stores in healthy neonatal rat cardiac myocytes and those isolated from adult rats with heart failure in a concentration-dependent manner; increases expression of Ryr2 and Serca2a and decreases expression of Ncx; reduces mortality and improves cardiac function in a rat model of congestive heart failure; inhibits doxorubicin-induced myocardial apoptosis and mitochondrial cytochrome C release in mice when preadministered at a dose of 1mg/kg per day for four days; induces cellular autophagy and inhibits growth of MCF-7 breast cancer cells and induces mitochondrial apoptosis in MGC803 and MKN26 gastric cancer cells |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CVB-D|NSC 91722 |
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| Gene, Accession, CAS # | CAS: 860-79-7 |
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| Catalog # | 22260-5 |
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| Order / More Info | Cyclovirobuxine D from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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