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| Antigenic Specificity | ITGA4/CD49D/Integrin alpha-4 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:2,000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ITGA4/CD49D/Integrin alpha-4 Polyclonal Antibody. Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. |
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| Immunogen | n/a |
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| Other Names | ITGB7, Gut homing receptor beta subunit, Integrin alpha-4/beta-7, Peyer patches-specific homing receptor LPAM-1, Itga4 |
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| Gene, Accession # | Entrez: 16401, 3676; Uniprot: P13612, Q00651 |
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| Catalog # | A305-255A |
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| Price | |
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| Order / More Info | ITGA4/CD49D/Integrin alpha-4 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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