| 产品详情 |
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| Product Name | 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine |
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| Description | A food-derived carcinogen; metabolized by CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts; chronic treatment (1 pM/L for 20 cycles) of MCF-10A cells induces anchorage-independent cell growth and reduces cellular dependence on growth factors; increases wild-type H-Ras gene and protein expression which activates ERK signaling, MMP-2 and MMP-9 protein expression, and NOX1-driven production of ROS in vitro; increases tumor formation in a murine breast cancer xenograft model; induces formation of colon tumors with β-catenin gene mutations that hyperactivate the Wnt signaling pathway in a CYP1A2 humanized rat model; increases the occurrence of atypical hyperplasias and carcinomas in the ventral prostate and seminal vesicles of rats, |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PhIP |
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| Gene, Accession, CAS # | CAS: 105650-23-5 |
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| Catalog # | 22590-10 |
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| Order / More Info | 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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