| 产品详情 |
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| Antigenic Specificity | VAV1 (pY174) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µl, 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | VAV1 (pY174) Antibody is a Rabbit Polyclonal antibody against VAV1 (pY174). This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
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| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1. |
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| Other Names | VAV1; p95vav; VAV; Vav 1 oncogene; Proto-oncogene vav |
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| Gene, Accession # | VAV1, Gene ID: 7409, SwissProt: P15498 |
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| Catalog # | abx000232 |
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| Price | |
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| Order / More Info | VAV1 (pY174) Antibody from ABBEXA |
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| Product Specific References | n/a |
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