| 产品详情 |
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| Antigenic Specificity | CD43 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | CF-Blue conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD43, the glycoprotein leukosialin (95-115kDa MW) antigen present on all T lymphocytes and on granulocytes, monocytes and platelets in peripheral blood. The antigen is also expressed cytoplasmically by macrophages. It is also present on all immature hematopoietic cells in the bone marrow. CD43 may be involved in the regulation of B, T and NK cell function. CD43 is a large single chain of type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites. Due to variable glycosylation and sialylation, two isoforms of CD43 have been identified. The 115 kD glycoform of CD43 is expressed on most hematopietic cells including T lymphocytes, NK cells, monocytes, granulocytes, platelets, and CD5+ B cells. It is not present on resting B cells and erythrocytes. While the 130 kD glycoform is thought to be activation-associated form primarily expressed on myeloid cells, pre-B cells, and activated T cells. It has been reported that CD43 binds to CD54 and Siglec-1. CD43 plays dual roles in cell adhesion and anti-adhesion, as well as costimulation of T cell activation and survival, and induction of apoptosis of T cells and hematopoietic progenitors. |
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| Immunogen | Native purified from myeloblastic KG1 Cells. |
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| Other Names | CD43; Ly-48; Leukosialin; Sialophorin; Leukocyte Sialoglycoprotein; gp115; MAb to CD43; Galactoglycoprotein; GALGP |
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| Gene, Accession # | Gene ID: 6693, SwissProt: P16150 |
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| Catalog # | abx200290 |
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| Price | |
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| Order / More Info | CD43 Antibody from ABBEXA |
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| Product Specific References | n/a |
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