| 产品详情 |
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| Antigenic Specificity | TPH2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, nonhuman primate, rabbit, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:500, Immunoprecipitation: 1:1,000, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TPH2 Polyclonal Antibody. Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protei |
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| Immunogen | n/a |
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| Other Names | Tryptophan 5-hydroxylase 1, NTPH |
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| Gene, Accession # | Entrez: 100344397, 121278, 216343, 317675; Uniprot: Q8CGU9, Q8CGV2, Q8IWU9 |
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| Catalog # | PA1-778 |
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| Price | |
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| Order / More Info | TPH2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 16581041, 24066056, 25289042, 25463023, 26219576, 27898359 |
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