| 产品详情 |
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| Product Name | DL-threo-PDMP (hydrochloride) |
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| Description | A PDMP mixture containing D-threo (1R,2R) and L-threo (1S,2S) PDMP; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | analog analogue inhibit inhibitor cytotoxicity glucosylceramide synthase chirality stereoisomer sphingosine (±)PDMP ceramide cultured cell treatment cellular cycle arrest alkaline cereamidase isomer β-1,4-galactosyltransferase 6 lactosylceramide neuroinflammation promoter mice mouse chronic autoimmune encephalomyelitis multiple sclerosis MS |
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| Gene, Accession, CAS # | CAS: 80938-69-8 |
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| Catalog # | 10005276-5 |
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| Order / More Info | DL-threo-PDMP (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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