| 产品详情 |
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| Antigenic Specificity | EP300 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | ascites |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA, WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | p300 is a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. |
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| Immunogen | Purified recombinant fragment of EP300 expressed in E. Coli. |
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| Other Names | E1A-associated protein p300; EP300; P300 transcription coactivator homolog; Histone acetyltransferase p300; P300; KAT3B; RSTS2 |
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| Gene, Accession # | EP300, Gene ID: 2033, SwissProt: Q09472 |
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| Catalog # | abx011304 |
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| Price | |
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| Order / More Info | EP300 Antibody from ABBEXA |
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| Product Specific References | n/a |
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