| 产品详情 |
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| Antigenic Specificity | JMJD6 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 50 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | JMJD6 Polyclonal Antibody. Jumonji domain containing 6 is a histone demethylating enzyme, which is active on arginine residues, but not lysines. Its activity destabilizes heterochromatin structures and activates gene expressions in euchromatin. In endothelial cells, the activity of JMJD6 is necessary for angiogenesis. If JMJD6 expression is reduced, the VEGF-receptor (Flt-1) is incorrectly spliced, leading to increased soluble Flt-1 which binds VEGF and PlGF and inhibits angiogenesis. JMJD6 also hydroxylates RNA splicing factors, and is important in embryonic differentiation. It most likely interacts specifically with single-stranded RNA, which may contribute to its early differentiation importance. |
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| Immunogen | n/a |
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| Other Names | PSR, PTDSR, PTDSR1, bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, histone arginine demethylase JMJD6, jmjC domain-containing protein 6, jumonji domain-containing protein 6, lysyl-hydroxylase JMJD6, peptide-lysine 5-dioxygenase JMJD6, phosphatidylserine receptor |
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| Gene, Accession # | Entrez: 23210; Uniprot: Q6NYC1 |
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| Catalog # | PA5-23089 |
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| Price | |
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| Order / More Info | JMJD6 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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