| 产品详情 |
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| Antigenic Specificity | SMNDC1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µl, 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SMNDC1 Antibody is a Rabbit Polyclonal antibody against SMNDC1. SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis. |
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| Immunogen | Recombinant protein of human SMNDC1. |
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| Other Names | SMNDC1; SMNR; SPF30; Survival of motor neuron-related-splicing factor 30; 30 kDa splicing factor SMNrp; SMN-related protein; Survival motor neuron domain-containing protein 1; TDRD16C |
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| Gene, Accession # | SMNDC1, Gene ID: 10285, SwissProt: O75940 |
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| Catalog # | abx000816 |
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| Price | |
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| Order / More Info | SMNDC1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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