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| Product Name | LY2784544 |
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| Description | A potent, ATP-competitive inhibitor of JAK2 that less effectively inhibits JAK3 (IC50s = 3 and 48 nM, respectively); inhibits JAK2 containing the V617F mutation (IC50 = 20 nM); reduces the growth of Ba/F3 pro-B-cells in SCID mice without affecting erythroid progenitors, reticulocytes, or platelets |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1229236-87-6 biochemical inhibitor kinase protein kinase cancer intracellular signaling signal transduction gandotinib LY 2784544 potent inhibit ATP-competitive janus kinase 2 JAK2 JAK JAK3 3 V617F mutation block STAT5 STAT 5 phosphorylation proliferation Ba/F3 pro-B-cells proB oral gavage reduce reduction growth SCID mice hematological malignancy malignancies |
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| Gene, Accession, CAS # | CAS: 1229236-86-5 |
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| Catalog # | 16705-25 |
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| Price | |
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| Order / More Info | LY2784544 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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