| 产品详情 |
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| Antigenic Specificity | AIRE |
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| Clone | 609930 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2A |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | lyophilized |
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| Applications | Flow Cytometry: 2.5 µg/1x10^6 cells, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | AIRE Monoclonal Antibody (609930). AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible |
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| Immunogen | n/a |
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| Other Names | AIRE1, APECED, APS1, APSI, PGA1, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein |
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| Gene, Accession # | Entrez: 11634; Uniprot: Q9Z0E3 |
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| Catalog # | MA5-24276 |
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| Price | |
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| Order / More Info | AIRE Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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