| 产品详情 |
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| Product Name | SAR407899 |
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| Description | An ATP-competitive inhibitor of ROCK-I and ROCK-II (IC50s = 102 and 276 nM, respectively at a concentration of 40 µM ATP); selective for ROCK over 79 other kinases at IC50 values up to 10 µM but had IC50 values ranging from 1 to 10 µM for RSK, PKB, PKCδ, and MSK-1; selective for ROCK over 115 receptor and enzyme targets at IC50 values up to 10 µM, but it does inhibit the serotonin transporter and μ-opioid receptors with IC50s values of 1.1 and 8.9 µM, respectively; inhibits ROCK-mediated phosphorylation of MYPT, thrombin-induced stress fiber formation, PDGF-induced proliferation, and MCP-1-stimulated chemotaxis; relaxes precontracted isolated arteries from various species (IC50s = 122-280 nM) and precontracted corpora cavernosa in both healthy and diabetic animals (IC50s = 0.05-0.42 µM); inhibits ET-1-induced constriction of rat and human arteries (Emaxs = 24-83% of control) |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SAR-407899 ROCKI ROCKII PKC-δ MSK1 ET1 |
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| Gene, Accession, CAS # | CAS: 923359-38-0 |
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| Catalog # | 21717-5 |
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| Price | |
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| Order / More Info | SAR407899 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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