| 产品详情 |
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| Antigenic Specificity | STUB1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA, WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | STUB1 Antibody is a Rabbit Polyclonal antibody against STUB1. The carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to the ubiquitin proteasome systemCytoplasmic CHIP protein contains three 34-amino acid TPR (tetRatricopeptide repeat) domains at its amino terminus and a carboxy-terminal U-box domainCHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, while E3 ubiquitin ligase activity is confined to the U-box domainThe binding of CHIP to Hsp70 can stall the folding of Hsp70 client proteins and concomitantly facilitate the U-box dependent ubiquitination of Hsp70-bound substRatesCHIP appears to play a central role in cell stress protection and is responsible for the degradation of disease-related proteins that include cystic fibrosis transmembrane conductance regulator, p53, huntingtin and Ataxin-3, Tau protein, and α-synuclein. |
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| Immunogen | Recombinant protein of human STUB1. |
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| Other Names | E3 ubiquitin-protein ligase CHIP; Antigen NY-CO-7; STUB1; CHIP; CLL-associated antigen KW-8; Carboxy terminus of Hsp70-interacting protein; STIP1 homology and U box-containing protein 1; HSPABP2; NY-CO-7; SDCCAG7; UBOX1 |
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| Gene, Accession # | STUB1, Gene ID: 10273, SwissProt: Q9UNE7 |
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| Catalog # | abx117049 |
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| Price | |
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| Order / More Info | STUB1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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