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| Product Name | NDT 9513727 |
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| Description | A competitive antagonist of C5aR (IC50 = 11.6 nM for the human recombinant receptor); has inverse agonist activity; selective for human recombinant over rat and mouse recombinant C5aRs (IC50 = >10 µM for both) but does have activity at macaque and gerbil receptors (IC50s = 7.3 and 6.4 nM, respectively); inhibits degranulation in C5a-stimulated U937 cells (IC50 = 7.1 nM); prevents C5a-induced neutropenia in gerbils (ED50 = 2.2 mg/kg) and in cynomolgus macaques at 5 and 25 mg/kg |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | CAS: 439571-48-9 |
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| Catalog # | 24448-10 |
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| Order / More Info | NDT 9513727 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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