| 产品详情 |
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| Product Name | Compound 43 TAO Kinase Inhibitor |
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| Description | An inhibitor of TAOKs (IC50s = 11 and 15 nM for TAOK1 and TAOK2, respectively); selective for TAOK1 and TAOK2 over 62 kinases in a panel, but does inhibit TAOK3 by 87% and seven additional kinases by 21-52%; inhibits proliferation of SK-BR-3, BT-549, and MCF-7 cells by 94, 82, and 46%, respectively, at a concentration of 10 µM; reduces tau phosphorylation in kinase assays at 5-60 µM and in HEK293 cells at 5, 10, and 30 µM; reduces tau phosphorylation in cortical neurons in a transgenic mouse model of tauopathy and in induced pluripotent stem cell-derived neurons from patients with frontotemporal lobar degeneration, |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TAOK-1 2 3 SK-BR-3 SKBR3 SK-BR3 BT549 MCF7 S-262 356 202 205 208 T-123 427 |
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| Gene, Accession, CAS # | CAS: 850467-66-2 |
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| Catalog # | 25632-10 |
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| Price | |
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| Order / More Info | Compound 43 TAO Kinase Inhibitor from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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