| 产品详情 |
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| Product Name | ON-123300 |
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| Description | A multi-kinase inhibitor; inhibits ARK5, Cdk4, and Cdk6 (IC50s = 3.87, 9.82, and 4.95 nM, respectively); inhibits FYN, PDGFRβ, Abl, and PI3Kδ (IC50s = 11.09, 26, 53.32, and 144 nM, respectively) among others; inhibits proliferation in a panel of 38 cancer cell lines (GI50s = 0.05-5 µM); also inhibits proliferation of U87 glioma cells (IC50 = 3.4 µM); reduces tumor growth in an MDA-MB-231 mouse xenograft model at 50 mg/kg every other day |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ON123300 CDK4 Ark-5 PDGFR-β FGFR1 PI3K-δ u-87 G2-M MDAMB MB231 MDAMB231cdk-4-6 |
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| Gene, Accession, CAS # | CAS: 1357470-29-1 |
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| Catalog # | 19902-5 |
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| Price | |
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| Order / More Info | ON-123300 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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