产品名称 Recombinant Mouse FcγRI/CD64 (carrier-free) from BIOLEGEND
产品货号 773806
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 BIOLEGEND
产品概述
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Product NameRecombinant Mouse FcγRI/CD64 (carrier-free)
DescriptionFcγRI, also known as CD64 and FcR I, is a type I transmembrane protein, belonging to the immunoglobulin superfamily. FcγRI is an Fc receptor that binds to monomeric IgG with high affinity. Human FcγRI binds to human IgG1, IgG3 and IgG4 with higher affinity, but no affinity for IgG2. However, murine FcγRI only binds to mouse IgG2a with high affinity, but it binds to mouse IgG2b and IgG3 with low affinity and no affinity for mouse IgG1. Upon binding to IgG, FcγRI associates with signal-transducing FcR common γ chain, and in turns conducts downstream signaling.  Though Fc γ chain is dispensable to FcγRI ligand-binding capacity, the surface expression of FcγRI and signaling are impaired in Fc γ chain-deficient cells.  FcγRI is exclusively expressed on myeloid cells, including monocytes/macrophages, dendritic cells, and inducible on neutrophils and mast cells. The expression can be upregulated by IFN-γ, IL-10 and G-CSF stimulation. Several studies demonstrated that FcγRI plays a role in antigen capture, IgG-induced cellular phagocytosis and antibody-dependent cellular cytotoxicity (ADCC). In FcγRI-deficient mouse macrophage, the IgG2a-induced phagocytosis and antibody-mediated killing were impaired. In addition, acute and chronic inflammatory responses and immune complex-dependent antigen presentation to primed T cells were disturbed in FcγRI-deficient mice.
Size100 µg
Concentrationn/a
ApplicationsBA
Other NamesHigh affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc gamma RI, FcRI, CD64, Fcg1, FcgR1
Gene, Accession, CAS #Gene ID: 14129
Catalog #773806
Price
Order / More InfoRecombinant Mouse FcγRI/CD64 (carrier-free) from BIOLEGEND
Product Specific Referencesn/a
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