| 产品详情 |
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| Antigenic Specificity | CD43 Activation-Associated Glycoform |
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| Clone | 1B11 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, κ |
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| Format | biotin conjugate |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Biotin anti-mouse CD43 Activation-Associated Glycoform. CD43, also known as Ly-48, Leukosialin, Sialophorin, Leukocyte Sialoglycoprotein, and gp115, is a large single chain of type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites. Due to variable glycosylation and sialylation, two isoforms of CD43 have been identified. The 115 kD glycoform of CD43 is expressed on most hematopietic cells including T lymphocytes, NK cells, monocytes, granulocytes, platelets, and CD5+ B cells. It is not present on resting B cells and erythrocytes. While the 130 kD glycoform is thought to be activation-associated form primarily expressed on myeloid cells, pre-B cells, and activated T cells. It has been reported that CD43 binds to CD54 and Siglec-1. CD43 plays dual roles in cell adhesion and anti-adhesion, as well as costimulation of T cell activation and survival, and induction of apoptosis of T cells and hematopoietic progenitors. The 1B11 antibody reacts with the activation-associated glycoform of CD43. The epitope recognized by 1B11 is also shared with desialylated CD45RB. This antibody is useful for differentiation of effector CD8 T cells and memory T cells. |
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| Immunogen | Mouse WEHI 274.3 myeloid tumor cells |
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| Other Names | Leukosialin, Ly-48, Sialophorin, gp115 |
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| Gene, Accession # | Gene ID: 20737 |
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| Catalog # | 121204 |
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| Price | |
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| Order / More Info | CD43 Activation-Associated Glycoform Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 18354208,20943997 |
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