| 产品详情 |
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| Antigenic Specificity | CDH1 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, monkey |
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| Isotype | IgG1 |
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| Format | ascites |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA, WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells.There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins.In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation.Its association with catenins is necessary for cell-cell adhesion.These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques.Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties.E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas.Increased expression of E-Cadherin in these cells reduces invasiveness.Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues. |
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| Immunogen | Purified recombinant fragment of human CDH1 expressed in E. coli. |
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| Other Names | CADH1; cadherin 1; type 1; E-cadherin (epithelial) (ECAD); cadherin-1; CAM 120/80; E-cadherin; epithelial-cadherin; uvomorulin; CDH1; Arc-1; CD324; CDHE; ECAD; LCAM; UVO; E-Cad/CTF3; Epithelial cadherin; E-Cad/CTF1; E-Cad/CTF2; Um; E-cad; L-CAM; AA960649; E-Cadherin, |
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| Gene, Accession # | Gene ID: 999 |
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| Catalog # | abx015807 |
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| Price | |
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| Order / More Info | CDH1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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