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| Product Name | 15(R)-15-methyl Prostaglandin D2 |
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| Description | The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle.{328,1185,580} PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1{3128} and CRTH2/DP2.{10722,9769} 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor.{10723} The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.{10723} |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 15(R)-15-methyl PGD2 |
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| Gene, Accession, CAS # | CAS: 210978-26-0 |
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| Catalog # | 12720-5 |
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| Order / More Info | 15(R)-15-methyl Prostaglandin D2 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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