| Description | A peptide hormone that lowers blood calcium levels and inhibits bone resorption; binds to CTR2 (IC50s = 8.5, 6.2, 10.7, and 5.8 nM for CTR2 alone and with RAMP1, 2, or 3, respectively); induces cAMP accumulation in RAECs expressing CTR2 alone, or co-transfected with RAMP1, 2, or 3 (EC50s = 0.07, 0.08, 0.05, and 0.99 nM, respectively); inhibits pit formation in dentine by GCT cells, rabbit osteoclasts, and mouse osteoclasts (ID50s = 0.19, 0.032, and 0.21 nM, respectively) |
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