| 产品详情 |
| Edit |   |
|---|
| Product Name | AGI-6780 |
|---|
| Description | A potent, selective inhibitor of mutant IDH2 (IC50 = 23 nM) that inhibits 2-HG formation in human glioblastoma U87 and TF-1 cells expressing IDH2-R140Q (IC50s = 11 and 18 nM, respectively); suppresses cell growth of primary human AML cells and induces differentiation of immature blast cells towards macrophage and granulocytic lineages |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | IDH inhibitors IDH2 isocitrate dehydrogenase α-ketoglutarate 2-OG glioma anti-tumor 2-hydroxyglutarate 2-HG IDH1 R140Q mutant AML leukemias differentiations therapy cancers therapies AGI6780 AGIs 6780 AGI 6780 potent selective inhibits inhibitions two IDH-2 2 HGs U87 U-87 Us 87 TF-1 TF1 TFs 1 one cells growths suppresses slineages macrophages franulocytic |
|---|
| Gene, Accession, CAS # | CAS: 1432660-47-3 |
|---|
| Catalog # | 14639-10 |
|---|
| Price | |
|---|
| Order / More Info | AGI-6780 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|