| 产品详情 |
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| Product Name | AGI-5198 |
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| Description | Selective inhibitor of IDH1 R132H and R132C mutants in vitro (IC50s = 0.07 and 0.16 µM, respectively) but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC50s > 100 µM); anti-tumor efficacy in vitro and in vivo; induces demethylation of histone H3K9me3 and expression of genes associated with gliogenic differentiation |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IDH-C35 IDHC35 IDH C35 inhibitors inhibits inhibitions isocitrates dehydrogenases IDH1 IDH-1 IDH 1 one α-ketoglutarate 2OG 2 OG two 2-OG gliomas antitumor anti tumors anti-tumors 2-hydroxyglutarate hydroxyglutarates HGs 2-HG R132H mutants histones demethylations gliogenesis AGI5198 AGI 5198 potent selectives R132C in vitro TS603 TS-603 xenografts H3K9me3 genes gliogenic differentiations cancers enzymes activity actives metabolisms NADs NADPs NAD-dependent NADP-dependent dependents tricarboxylic acids cycles catalyzes oxidatives decarboxylations alpha ketoglutarates alpha-ketoglutarate carbons dioxides IDH1 IDH2 mutated mutations maps arginines residues catalytic pockets gains of functions NADPH-dependent NADPHs conversion AGI-5198 wild-type wilds types cells lines growths treatments periods induces expressions |
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| Gene, Accession, CAS # | CAS: 1355326-35-0 |
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| Catalog # | 14624-25 |
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| Order / More Info | AGI-5198 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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