| 产品详情 |
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| Antigenic Specificity | CD223 |
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| Clone | 11C3C65 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | Brilliant Violet 650™ conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Brilliant Violet 650™ anti-human CD223 (LAG-3). CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved in T-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223 negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells (NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated T-cells in acute conditions but high expression is maintained under tolerizing conditions. CD223 deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverse exhausted phenotypes, improve tumor rejection, and control viral load. |
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| Immunogen | Human LAG-3 transfected cells. |
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| Other Names | CD223, LAG-3, LAG3, lymphocyte-activation gene-3 |
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| Gene, Accession # | Gene ID: 3902 |
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| Catalog # | 369316 |
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| Price | |
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| Order / More Info | CD223 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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