| 产品详情 |
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| Antigenic Specificity | NCSTN |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NCSTN Antibody is a Rabbit Polyclonal antibody against NCSTN. This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. |
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| Immunogen | Recombinant protein of human NCSTN. |
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| Other Names | APH2; RP11-517F10.1; NCSTN; KIAA0253 |
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| Gene, Accession # | NCSTN, Gene ID: 23385, SwissProt: Q92542 |
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| Catalog # | abx001020 |
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| Price | |
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| Order / More Info | NCSTN Antibody from ABBEXA |
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| Product Specific References | n/a |
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