| 产品详情 |
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| Antigenic Specificity | IL-34 |
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| Clone | E0320E7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, λ |
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| Format | purified |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | ELISA Capture |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human IL-34. Human IL-34 shares a sequence identity of 99.6%, 72% and 71% with chimpanzee, rat, and mouse IL-34, respectively, on the amino acid level. The IL-34 gene is syntenic in the human, chimpanzee, rat, and mouse genomes. IL-34 has no apparent consensus structural domain or motif, and does not share sequence homology with M-CSF; nevertheless, it binds to the CSFR. These two cytokines are not identical in biological activity and signal activation. IL-34 and CSF show an equivalent ability to support cell growth or survival. However, these cytokines are differing in their ability to induce the production of chemokines (MCP-1 and eotaxin-2) in primary macrophages, the morphological change in TF-1-fms cells, and the migration of J774A.1 cells. The use of monoclonal antibodies against the CSFR suggests differential domain binding of the receptor to IL-34 and CSF and as a result, different bioactivities and signal activation kinetics/strength are produced for these cytokines. |
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| Immunogen | Recombinant human IL-34 |
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| Other Names | Interleukin 34, IL34, C16orf77 |
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| Gene, Accession # | Gene ID: 146433 |
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| Catalog # | 361302 |
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| Price | |
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| Order / More Info | IL-34 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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