| 产品详情 |
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| Antigenic Specificity | Bax |
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| Clone | 6A7 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat, monkey |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Bax. Bax is a 21 kD pro-apoptotic protein known to regulate apoptosis. Bax is found in the cytoplasm, mitochondria, and nucleus and is highly expressed in hematopoietic stem cells, the ovary, and in the lymph node. Bax binds the anti-apoptotic protein Bcl-2 as a heterodimer or forms homodimers. The relative levels of pro-apoptotic proteins such as Bax and anti-apoptotic proteins such as Bcl-2 determines whether cell death will occur following an apoptotic stimulus. Bax accelerates the opening of mitochondrial VDAC altering membrane potential and allowing cytochrome c to pass out of the mitochondria into the cytosol to initiate downstream caspase activation. p53 can transcriptionally activate the Bax gene to induce apoptosis. Bax has been shown to be mutated in some human cancers. Clone 2D2 has been shown to be useful for western blotting, immunoprecipitation, immunofluorescence and immunohistochemistry of the human Bax protein.This antibody does not cross-react with Bcl-2 or Bcl-XL proteins. |
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| Immunogen | Amino acid:12-24 common to human, mouse, and rat Bax protein |
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| Other Names | BCL2 associated X protein, apoptosis regulator Bax |
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| Gene, Accession # | Gene ID: 581 |
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| Catalog # | 633802 |
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| Price | |
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| Order / More Info | Bax Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 23904165 |
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