| 产品详情 |
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| Antigenic Specificity | CIP2A |
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| Clone | 2A1-9A4 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 20 µL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 20 µL/1 mg lysate, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CIP2A Monoclonal Antibody (2A1-9A4). Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNS |
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| Immunogen | n/a |
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| Other Names | Cancerous Inhibitor of Protein Phosphatase 2A , p90 |
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| Gene, Accession # | Entrez: 224171, 57650; Uniprot: Q8BWY9, Q8TCG1 |
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| Catalog # | A500-010A-T |
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| Price | |
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| Order / More Info | CIP2A Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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