| 产品详情 |
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| Product Name | LY2090314 |
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| Description | A potent and selective inhibitor of GSK3 (IC50s = 1.5 and 0.9 for human recombinant GSK3α and GSK2β, respectively); has >10-fold selectivity for GSK3 against a panel of 40 kinases at a concentration of 20 µM; induces time-dependent stabilization of β-catenin total protein and activates Wnt signaling in vitro; has potent antiproliferative activity in BRAF wild-type/NRAS mutant and BRAF mutant melanoma cell lines (IC50s = 6.0-11.8 nM) but has limited to no activity in non-melanoma cell lines (IC50s = 430 to >20,000 nM); knockdown of β-catenin in A375 and M14 melanoma cells induces LY2090314 resistance in vitro; reduces tumor volume in a murine A375 xenograft model as a single agent and synergizes with decabarzine for a greater antitumor effect, |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LY-2090314 GSK3α/β GSK3α GSK3β α β GSK-3α/β GSK-3α GSK-3β |
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| Gene, Accession, CAS # | CAS: 603288-22-8 |
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| Catalog # | 22211-5 |
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| Price | |
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| Order / More Info | LY2090314 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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