| 产品详情 |
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| Product Name | AM1241 |
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| Description | A CB2 receptor agonist; selective for CB2 over CB1 (Kis = 7.1 and 580 nM); considered a protean agonist because it has neutral antagonist and partial agonist activity, depending on the assay utilized; acts in a species-dependent manner in vitro, acting as an agonist at human CB2 receptors (EC50 = 190 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 216 and 463 nM, respectively); produces antinociception to thermal stimuli in rat hindpaw; neuroprotective, preventing Gp120-induced apoptosis in vitro and increasing survival and differentiation of neural progenitor cells; increases hippocampal neurogenesis in GFAP/Gp120 transgenic mice when administered at a dose of 10 mg/kg daily for ten days; delays motor impairment in a murine model of ALS |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CB-1 2 AM-1241 Gp-120 HIV1 |
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| Gene, Accession, CAS # | CAS: 444912-48-5 |
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| Catalog # | 10010118-5 |
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| Order / More Info | AM1241 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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