| 产品详情 |
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| Antigenic Specificity | ATRIP |
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| Clone | OTI9A4 |
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| Host Species | Mouse |
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| Reactive Species | cynomolgus monkey, human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ATRIP Monoclonal Antibody (OTI9A4). ATR- interacting protein (ATRIP) is an essential component of the DNA damage checkpoint pathway. ATRIP, phosphorylated by ataxia telangiectasia mutated and Rad3 kinase (ATR), regulates ATR expression, signifying their mutual dependence. The ATR-ATRIP protein kinase complex is essential for the cellular response to replication stress and DNA damage. It has been shown, in vitro, that replication protein A (RPA) stimulates the binding of ATRIP to single-stranded DNA. This enables the ATR-ATRIP complex to associate with DNA and stimulates phosphorylation of the RAD17 protein that is bound to DNA. ATR/ATRIP exist as a large molecular weight complex that can bind single-stranded DNA cellulose in vitro. Neither |
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| Immunogen | n/a |
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| Other Names | 3' Repair Exonuclease 1, ATR interacting protein, ATRIP, Deoxyribonuclease III, DRN3, FLJ12343, Three Prime Repair Exonuclease 1, TREX1 |
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| Gene, Accession # | Entrez: 710035, 84126; Uniprot: Q8WXE1, Q9N077 |
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| Catalog # | MA5-25944 |
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| Price | |
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| Order / More Info | ATRIP Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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