| 产品详情 |
| Edit |   |
|---|
| Product Name | FR122047 (hydrate) |
|---|
| Description | FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 µM, respectively.{11222} In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin.{10791} Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.{10672} |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 130717-51-0 FR-122047 cyclooxygenases COX-1 inhibitors hydrates hydrochlorides COX1 PGHS1 PGHS-1 prostaglandin synthases inhibition inhibits selective selectivity platelet aggregation antiinflammatory atherosclerosis |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 10039-10 |
|---|
| Price | |
|---|
| Order / More Info | FR122047 (hydrate) from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|