| 产品详情 |
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| Product Name | HKI 357 |
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| Description | An irreversible dual inhibitor of EGFR and HER2 (IC50s = 34 and 33 nM, respectively); inhibits proliferation of A431, SK-BR-3, and SW620 cancer cell lines (IC50s = 120, 2.5, and 511 nM, respectively); suppresses EGFR autophosphorylation and phosphorylation of the downstream effectors AKT and ERK in NCI-H1650 and NCI-H1650(G7) cells; inhibits tumor growth in BT474, A431, and SUM190 mouse xenograft models (10 mg/kg) , |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HKI357 A-431 SKBR3 BR3 SKBR SW-620 NCIH1650 BT-474 SUM-190 |
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| Gene, Accession, CAS # | CAS: 848133-17-5 |
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| Catalog # | 14847-5 |
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| Price | |
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| Order / More Info | HKI 357 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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