| 产品详情 |
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| Antigenic Specificity | ATR |
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| Clone | 2B5 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Functional Assay: Assay Dependent, Immunocytochemistry: Assay-dependent, Immunofluorescence: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: 1:500-1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ATR Monoclonal Antibody (2B5). The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK s |
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| Immunogen | n/a |
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| Other Names | FRP1, MEC1, SCKL, SCKL1 |
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| Gene, Accession # | Entrez: 545; Uniprot: Q13535 |
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| Catalog # | MA1-23158 |
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| Price | |
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| Order / More Info | ATR Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 26850987, 8576576 |
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