| 产品详情 |
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| Product Name | RAF709 |
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| Description | A potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively); selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases; DDR1, DDR2, FRK, and PDGFRβ are also inhibited by >80% at a concentration of 1 µM; inhibits phosphorylation of MEK and ERK (EC50s = 0.02 and 0.1 µM, respectively) with minimal paradoxical activation, stabilizes BRAF-CRAF dimers (EC50 = 0.8 µM), and reduces proliferation of Calu-6 RAS mutant cells (EC50 = 0.95 µM); reduces ERK phosphorylation and decreases tumor volume without affecting total body weight in a Calu-6 mouse NSCLC xenograft model when administered at doses ranging from 10-200 mg/kg |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RAF-709 BRAF-V600E CRAF DDR-1 2 PDGFRb Calu6 PDGFR-β |
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| Gene, Accession, CAS # | CAS: 1628838-42-5 |
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| Catalog # | 23820-5 |
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| Price | |
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| Order / More Info | RAF709 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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