| 产品详情 |
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| Product Name | API-1 |
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| Description | An Akt inhibitor that reduces the level of phosphorylated Akt (IC50 = ~0.8 µM); binds Akt and blocks its translocation to the cell membrane; reduces cell proliferation in cancer cell lines, induces apoptosis, and, at a dose of 10 mg/kg/day, decreases tumor growth in a mouse xenograft model; inhibits cell growth (IC50s = 2-5 µM) and induces apoptosis in NSCLC and HNSCC cell lines; increases cleavage of caspases 8, 9, and 3; reduces c-FLIP levels through ubiquitin/proteasome-mediated degradation; synergistically induces apoptosis in combination with TRAIL/APO-2L |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NSC 177223 |
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| Gene, Accession, CAS # | CAS: 36707-00-3 |
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| Catalog # | 22081-10 |
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| Price | |
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| Order / More Info | API-1 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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