| 产品详情 |
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| Product Name | Tafamidis |
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| Description | A TTR kinetic stabilizer; binds to TTR with negative cooperativity (Kd1 = 3 nM; Kd2 = 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation; stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s = 2.7-3.2 µM) under fibril-promoting, denaturing, and physiological conditions in vitro; stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 µM, |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PF-06291826 |
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| Gene, Accession, CAS # | CAS: 594839-88-0 |
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| Catalog # | 13694-5 |
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| Price | |
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| Order / More Info | Tafamidis from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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