| 产品详情 |
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| Product Name | AUDA |
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| Description | AUDA is an inhibitor of sEH exhibiting IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively.{14064} In angiotensin-infused rats, a dose of 25 mg/l AUDA administered in drinking water decreased mean arterial blood pressure from 161 ± 4 mmHg to 140 ± 5 mmHg. This hypotensive effect was accompanied by an increase in urinary epoxide-to-diol ratios.{14065} AUDA activates PPARα 3-fold at a concentration of 10 µM but exhibits no affect on PPAR.delta. or PPARγ.{13447} |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | epoxides hydrolases hypertension dihydroxy-eicosatrienoic acids DHETs 11(12)-EETs 14(15)-EETs blood pressure soluble sEH inhibits inhibitors inhibition peroxisome proliferator-activated receptors PPARalpha PPAR.alpha. DiHETrEs EpETrEs endocrinology |
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| Gene, Accession, CAS # | CAS: 479413-70-2 |
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| Catalog # | 10007927-10 |
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| Order / More Info | AUDA from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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