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| Product Name | LCL-161 |
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| Description | A Smac mimetic and inhibitor of IAP family proteins; inhibits growth of FLT3-ITD-expressing leukemia cells via induction of apoptosis (IC50s = 0.5-4 µM); enhances growth inhibition driven by PKC 412 in a mouse Ba/F3-FLT3-ITD-luc+ leukemia xenograft model; exhibits additive effects with the chemotherapeutic agents doxorubicin and cytarabine; inhibits growth of nilotinib-resistant leukemia cell lines and exhibits synergy with nilotinib in a Bcr-Abl expressing, 32D.p20-luc+ leukemia mouse xenograft model |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NVP-LCL161 |
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| Gene, Accession, CAS # | CAS: 1005342-46-0 |
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| Catalog # | 22420-50 |
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| Price | |
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| Order / More Info | LCL-161 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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