| 产品详情 |
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| Antigenic Specificity | EFCAB4B |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | peptide affinity purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Ca (2+) binding protein that plays a key role in store-operated Ca (2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca (2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca (2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. This EFCAB4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B. |
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| Immunogen | Human EFCAB4B. |
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| Other Names | EFCAB4B; CRACR2A; EF-hand calcium-binding domain-containing protein 4B; Calcium release-activated calcium channel regulator 2A |
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| Gene, Accession # | EFCAB4B, SwissProt: Q9BSW2 |
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| Catalog # | abx029908 |
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| Price | |
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| Order / More Info | EFCAB4B Antibody from ABBEXA |
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| Product Specific References | n/a |
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| 产品资料 |
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